4-Quinolinamine, 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)-
GAK inhibitor 49
CAS: 319492-82-5
Molecular Formula: C20H22N2O5
4-Quinolinamine, 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)- - Names and Identifiers
| Name | GAK inhibitor 49 |
| Synonyms | GAK inhibitor 49 6,7-Dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine 4-Quinolinamine, 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)- |
| CAS | 319492-82-5 |
4-Quinolinamine, 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)- - Physico-chemical Properties
| Molecular Formula | C20H22N2O5 |
| Molar Mass | 370.4 |
| Density | 1.223±0.06 g/cm3(Predicted) |
| Boling Point | 494.8±45.0 °C(Predicted) |
| pKa | 7?+-.0.50(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | GAK inhibitor 49 (compound 49) shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC 50 s of 28, 63 and >100 μM, respectively. |
4-Quinolinamine, 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
| 10 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
Last Update：2024-01-02 23:10:35
4-Quinolinamine, 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)- - Reference Information
| biological activity | GAK inhibitor 49 is an ATP-competitive, highly selective cyclin G-related kinase (GAK) inhibitors, Ki is 0.54 nM, cell IC50 is 56 nM. GAK inhibitor 49 was also shown to bind to ripk2. |
Last Update：2024-04-09 22:09:11
